$7,748,800
2275 Highway F
Defiance, MO, 63341
Imagine owning a timeless piece of Missouri history. More than 250 years ago, the Osage people traveled these valleys, and pioneers like Daniel Boone, his son Nathan and nephew/adopted son Jonathan Bryan helped shape this remarkable landscape. A captivating driveway leads around to a ONE-OF-A-KIND property built in the 1840’s for Jonathan Bryan. “Bryan Mill” rests gracefully on 105.4+/- acres providing a peaceful & tranquil atmosphere, conveniently located near Augusta & Defiance, with a STRIKING, FINELY DETAILED, FULLY FURNISHED, FRENCH INSPIRED w/exquisite imported antiques curated by Annie Brahler of EuroTrash, Inc. At the heart of the property is an 1840s built cottage exquisitely reimagined as a luxurious country residence, and STATELY early 1800’s built 68’x36’ Stone mill/outbuilding with 2 BEAUTIFUL automatic solid wood doors, floor-to-ceiling Stone fireplace, 37’+/- vaulted ceiling, kitchen, 2 half baths, & an abundant amount of storage space, AND a COMPLETELY REDONE stone chicken coop. Throughout the cottage, historic details have been carefully preserved and complemented by modern mechanical systems, conveniences, and automated security and surveillance. The home boasts 2,815+/- SqFt, 5 bedrooms, 2 full baths, with mostly original hardwood flooring throughout and a kitchen anchored by a 65 inch La Cornue Chateau Series range. The historic mill is equally remarkable. Beautifully restored and fully climate-controlled with modern HVAC systems, the mill features a catering kitchen and expansive event and entertaining spaces. It offers an extraordinary setting for private dinners, celebrations, retreats, creative pursuits, or large-scale entertaining—all without ever leaving the privacy of the estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. Beyond the residence, private acreage unfold through rolling fields, mature woods, gardens, and majestic private pathways winding throughout the estate. A dramatic boulder firepit creates an intimate destination for evenings outdoors, while even the custom chicken coop has been thoughtfully designed to complement the architecture and character of the property. Opportunities to own a tract with this combination of history, natural beauty, privacy, and location are exceptionally rare, especially with frontage on the coveted Hwy F. This isn’t just land—it’s a place where your family’s next chapter can begin and memories can be made for generations to come. MUST SEE! Today, you have the rare opportunity to own 105.4+/- acres of beautiful land just off Highway F, conveniently located near Augusta and Defiance, with over $1,000,000 of road and infrastructure improvements completed creating multiple opportunities for building sites on the property with electric, well and septic in place. With breathtaking ridge-top views and rolling countryside, this property is the perfect setting for a private family retreat, a picturesque mini ranch, or private equestrian estate. Create a legacy where your children and grandchildren can reconnect with nature—plant gardens, raise animals, ride horses, explore miles of side-by-side trails, or simply enjoy the peace and beauty that only a property like this can offer. *ALL PARTIES UNDERSTAND PROPERTY IS SUBJECT TO SURVEY AND APPROVED THROUGH CITY & ALL GOVERNMENTAL AUTHORITIES.* Seller will also consider dividing the property in different ways. Acreage sold SEPARATELY. See MLS #’s: 26053202 (LOT #1, 22+/- ACRES), 26053203 (LOT #2, 12.5+/- ACRES), 26053360 (LOT #3, 38.5+/- ACRES), & 26053204 (LOT #4, 32+/- ACRES).
Property Details
Price:
$7,748,800
MLS #:
MIS26057899
Status:
Active
Beds:
5
Baths:
4
Type:
Single Family
Subtype:
Single Family Residence
Neighborhood:
412francishowellcntrl
Listed Date:
Sep 8, 2026
Finished Sq Ft:
2,815
Lot Size:
4,591,224 sqft / 105.40 acres (approx)
Year Built:
1843
Schools
School District:
Francis Howell R-III
Elementary School:
Daniel Boone Elem.
Middle School:
Francis Howell Middle
High School:
Francis Howell Central High
Interior
Above Grade Finished Area
2815
Appliances
Dishwasher, Disposal, Built-In Freezer, Range Hood, Gas Range, Built-In Refrigerator, Washer/Dryer, Tankless Water Heater, Water Purifier
Bathrooms
2 Full Bathrooms, 2 Half Bathrooms
Cooling
Central Air, Electric
Fireplaces Total
3
Heating
Forced Air
Interior Features
Beamed Ceilings, Built-in Features, Center Hall Floorplan, Chandelier, Eat-in Kitchen, Entrance Foyer, Natural Woodwork, Recessed Lighting, Smart Thermostat, Sound System, Vaulted Ceiling(s)
Laundry Features
In Basement
Levels
Three Or More
Main Level Bedrooms
1
Exterior
Architectural Style
Colonial, French Provincial, Historic, Traditional
Construction Materials
Stone
Exterior Features
Fire Pit, Private Entrance
Lot Features
Cleared, Many Trees, Meadow, Pasture, Scattered Woods
Patio And Porch Features
Front Porch, Patio, Rear Porch
Roof
Wood
Security Features
Security System, Security System Owned
Window Features
Window Coverings
Financial
Kahn & Busk Real Estate Partners have earned the top team spot at Coldwell Banker Premier Group for several years in a row! We are dedicated to helping our clients with all of their residential real estate needs. Whether you are a first time buyer or looking to downsize, we can help you with buying your next home and selling your current house. We have over 25 years of experience in the real estate industry in Eureka, St. Louis and surrounding areas.
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Map
Current real estate data for Single Family in Defiance as of Sep 15, 2026
21
Single Family Listed
55
Avg DOM
391
Avg $ / SqFt
$1,224,012
Avg List Price
Community
- Address2275 Highway F Defiance MO
- SubdivisionN/A
- CityDefiance
- CountySt. Charles
- Zip Code63341
Subdivisions in Defiance
- August Estates
- Callaway Farms #2
- Callaway Lake Estate
- Callaway Lake Estates
- CALLAWAY VALLEY
- Callaway Valley #1
- Callaway Valley #6 Resub
- Coleman Farm #1
- Country Oaks #4
- Crown Pointe Farms
- Estates at Callaway Lake
- Hidden Vista Estate
- Indian Ridge Farms
- Lakeway
- Manors At Kohlers Grove
- Markham Hills
- None Unrestricted
- Old Colony Farms
- Saddleback
- Steeple Rock Point
- Sunset Estates
- Wilderness
- Wilderness #2
Similar Listings Nearby
Property Summary
- Located in the N/A subdivision, 2275 Highway F Defiance MO is a Single Family for sale in Defiance, MO, 63341. It is listed for $7,748,800 and features 5 beds, 4 baths, and has approximately 2,815 square feet of living space, and was originally constructed in 1843. The current price per square foot is $2,753. The average price per square foot for Single Family listings in Defiance is $391. The average listing price for Single Family in Defiance is $1,224,012.

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2275 Highway F
Defiance, MO
























































